Jesse Brown

[Name]

NPI B8-169 | 310.825.9334

About Me

I'm a Ph.D. candidate in the Neuroscience IDP at UCLA.

My research is in multimodal neuroimaging of human episodic memory systems in health and neurodegeneration. Currently, I use DTI and fMRI to study connections between the hippocampus and the prefrontal cortex in normal individuals and those at greater genetic risk for developing Alzheimer's Disease. Graph theory and machine learning have become a central part of my thesis.

More generally, I'm interested in memory, early detection of neurological disease states, human brain evolution, and cognitive enhancement/augmentation.

Curriculum Vitae

My CV.

Publications

Jesse A. Brown, Jeffrey D. Rudie, Anita Bandrowski, John D. Van Horn and Susan Y. Bookheimer.
The UCLA multimodal connectivity database: a web-based platform for brain connectivity matrix sharing and analysis (2012). Frontiers in Neuroinformatics.
10.3389/fninf.2012.00028 | PDF

JD Rudie, JA Brown, D Beck-Pancer, LM Hernandez, EL Dennis, PM Thompson, SY Bookheimer, M Dapretto.
Altered Functional and Structural Brain Network Organization in Autism (2012). Neuroimage: Clinical. 15 November 2012.
10.1016/j.nicl.2012.11.006 | PDF

J.D. Rudie, L.M. Hernandez, J.A. Brown, D. Beck-Pancer, N.L. Colich, P. Gorrindo, P.M. Thompson, D.H. Geschwind, S.Y. Bookheimer, P. Levitt, and M. Dapretto.
Autism-Associated Promoter Variant in MET Impacts Functional and Structural Brain Networks (2012). Neuron. Sep 6; 75(5):904-15.
10.1016/j.neuron.2012.07.010 | PDF

Jesse A. Brown, Kevin H. Terashima, Alison C. Burggren, Linda M. Ercoli, Karen J. Miller, Gary W. Small, Susan Y. Bookheimer (2011).
Brain network local interconnectivity loss in aging APOE-4 allele carriers. Proc Natl Acad Sci.
10.1073/pnas.1109038108 | PDF

John B. Colby, Jeffrey D. Rudie, Jesse A. Brown, Pamela K. Douglas, Mark S. Cohen and Zarrar Shehzad (2012).
Insights into multimodal imaging classification of ADHD. Frontiers in Systems Neuroscience.
10.3389/fnsys.2012.00059

Emily L. Dennis, Neda Jahanshad, Jeffrey D. Rudie, Jesse A. Brown, Kori Johnson, Katie L. McMahon, Greig I. de Zubicaray, Grant Montgomery, Nicholas G. Martin, Margaret J. Wright, Susan Y. Bookheimer, Mirella Dapretto, Arthur W. Toga, Paul M. Thompson.
Abnormal Structural Brain Connectivity in Healthy Carriers of the Autism Risk Gene, CNTNAP2. Brain Connectivity. 2012 Feb 29.
10.1089/brain.2011.0064 | PDF

Danielle S. Bassett, Jesse A. Brown, Vibhas Deshpande, Jean M. Carlson, Scott T. Grafton.
Conserved and variable architecture of human white matter connectivity. Neuroimage 54(2):1262-79 (2011).
10.1016/j.neuroimage.2010.09.006

Natcha Opalka, Jesse Brown, William J. Lane, Kelly-Anne F. Twist, Robert Landick, Francisco J. Asturias, Seth A. Darst.
Complete Structural Model of Escherichia coli RNA Polymerase from a Hybrid Approach. PLoS Biology 8(9): e1000483 (2010).
10.1371/journal.pbio.1000483

Yuchiro Takagi, Guillermo Calero, Hirofumi Komori, Jesse A. Brown, Andres Ehrensberger, Andy Hudmon, Francisco J. Asturias, Roger D. Kornberg.
Head Module Control of Mediator Interactions. Molecular Cell 23:355-364 (2006).
10.1016/j.molcel.2006.06.007

DTI
Notes on DTI analysis including image processing, tractography, and group statistical comparisons. Also includes links to useful DTI image converters, FSL sites of interest, and papers on DTI fundamentals.

UMCD
UCLA Multimodal Connectivity Database is a site for web-based brain network analysis where researchers can share their own connectivity data and interact with other publicly shared data. It is supported by the MGH-UCLA Human Connectome Project.

Functional Connectivity
References for performing different functional connectivity analyses, including resting state analysis and PPI using FSL.

UMCP
UCLA Multimodal Connectivity Package is a set of programs I've written for calculating structural and functional connectivity metrics from diffusion weighted MRI and fMRI.

New blog
Old blog
Musings on new tools, new papers, conferences, and other miscellany.

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